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KMID : 0438219720090020197
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Korea University Medical Journal
1972 Volume.9 No. 2 p.197 ~ p.205
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Effects of Sympathomimetics on the Circulatory System of Male and Female Rabbits Pretreated with Testosterone
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Kim Soon-Young
Shin Man-Ryun
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Abstract
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In order to investigate the influence of testosterone to the effects of both norepinephring and phenylephrine on the circulatory system of both male and female rabbits, the responses of blood pressure, and contractilities of both isolated auricle and aortic strips of male and female rabbits pretreated using testosterone of 1 or 2 week´s duration have been observed following administration of norepinepbrine and phenylephrine respectively.
The results obtained were as follows;
1. The testosterone treatment of 1 or 2 week´s duration usually tended to decrease the blood pressure of both male and female rabbits. Especially the blood pressure of the female rabbits when it was on treatment of testosterone for 2 weeks was significantly decreased.
2. The testosterone pretreatment of 1 or 2 week´s duration resulted in marked increase on the pressor response of female rabbits when it was induced by norepinephrine, but showed no any effect on the pressor response when it was induced by phenylephrine.
3. The testosterone pretreated revealed no effect on the contractility of isolated auricle induced by norepinephrine, but tended to depress the contractility when it was induced by phenylephrine, particularly the contractility of the isolated auricle of both male and female rabbits showed marked decrease when it was pretreated with testosterone for 2 weeks.
4. The testosterone pretreated did not effects on the contractility of isolated aortic strips induced by norepinephrine, but showed marked increase on its contractility when it has induced by phenylephrine in both male and female rabbits pretreated testosterone for 2 weeks.
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